Can I run MiniCPM5-2B-DSpark on a Mac with 192 GB?

Yes

Its published weights (648 MB) fit in the 144 GB a Mac with 192 GB can use, with room for ≈ 128K tokens of context.

Full analysis of MiniCPM5-2B-DSpark Everything that runs on Mac with 192 GB Get the weights on Hugging Face

hf download openbmb/MiniCPM5-2B-DSpark

Files and context on Mac with 192 GB

Each file of MiniCPM5-2B-DSpark (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On Mac with 192 GB	Context (16-bit)	Context (8-bit)
As published	648 MB	Fits	128K	128K
4-bit (estimate)	182 MB	Fits	128K	128K

MiniCPM5-2B-DSpark on other hardware

NVIDIA H100Yes
RTX 5090Yes
RTX 4090Yes
RTX 3090Yes
RTX 5060 Ti 16 GBYes
RTX 3060 12 GBYes
RTX 4060Yes
Mac with 32 GBYes
Mac with 64 GBYes
Mac with 128 GBYes
Mac with 192 GBYes

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Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.