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Can I run MiniCPM5-2B-GGUF on a Mac with 64 GB?

Yes

Its F16 file (5.04 GB) fits in the 48.0 GB a Mac with 64 GB can use, with room for ≈ 128K tokens of context.

Full analysis of MiniCPM5-2B-GGUF Everything that runs on Mac with 64 GB Get the F16 file on Hugging Face
ollama run hf.co/openbmb/MiniCPM5-2B-GGUF:F16

Files and context on Mac with 64 GB

Each file of MiniCPM5-2B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 64 GB Context (16-bit)Context (8-bit)
F165.04 GBFits128K128K
Q8_02.68 GBFits128K128K
Q4_K_M1.56 GBFits128K128K

MiniCPM5-2B-GGUF on other hardware

Popular models that run on Mac with 64 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.