Can I run MiniCPM5-2B on an RTX 5060 Ti 16 GB?

Yes

Its published weights (5.03 GB) fit in the 14.4 GB an RTX 5060 Ti 16 GB can use, with room for ≈ 128K tokens of context.

Full analysis of MiniCPM5-2B Everything that runs on RTX 5060 Ti 16 GB Get the weights on Hugging Face

hf download openbmb/MiniCPM5-2B

Files and context on RTX 5060 Ti 16 GB

Each file of MiniCPM5-2B (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On RTX 5060 Ti 16 GB	Context (16-bit)	Context (8-bit)
As published	5.03 GB	Fits	128K	128K
F16openbmb/MiniCPM5-2B-GGUF	5.04 GB	Fits	128K	128K
Q8_0openbmb/MiniCPM5-2B-GGUF	2.68 GB	Fits	128K	128K
Q4_K_Mopenbmb/MiniCPM5-2B-GGUF	1.56 GB	Fits	128K	128K

MiniCPM5-2B on other hardware

Popular models that run on RTX 5060 Ti 16 GB

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.