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Can I run Ornith-1.0-35B-GGUF on a Mac with 48 GB?

Yes

Its Q6_K file (28.5 GB) fits in the 36.0 GB a Mac with 48 GB can use, with room for ≈ 256K tokens of context.

Full analysis of Ornith-1.0-35B-GGUF Everything that runs on Mac with 48 GB Get the Q6_K file on Hugging Face
ollama run hf.co/ornith-ai/Ornith-1.0-35B-GGUF:Q6_K

Files and context on Mac with 48 GB

Each file of Ornith-1.0-35B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 48 GB Context (16-bit)Context (8-bit)
BF1669.4 GBDoesn't fit——
Q8_036.9 GBDoesn't fit——
Q6_K28.5 GBFits256K256K
Q5_K_M24.7 GBFits256K256K
Q4_K_M21.2 GBFits256K256K

Ornith-1.0-35B-GGUF on other hardware

Popular models that run on Mac with 48 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.