Can I run Oc-e-Non-v1 on an RTX 5080?

Yes

Its published weights (8.04 GB) fit in the 14.4 GB an RTX 5080 can use, with room for ≈ 42K tokens of context.

Full analysis of Oc-e-Non-v1 Everything that runs on RTX 5080 Get the weights on Hugging Face

hf download p-e-w/Oc-e-Non-v1

Files and context on RTX 5080

Each file of Oc-e-Non-v1 (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On RTX 5080	Context (16-bit)	Context (8-bit)
As published	8.04 GB	Fits	42K	84K
4-bit (estimate)	2.26 GB	Fits	80K	161K

Oc-e-Non-v1 on other hardware

NVIDIA H100Yes
RTX 5090Yes
RTX 4090Yes
RTX 3090Yes
RTX 5080Yes
RTX 5060 Ti 16 GBYes
RTX 3060 12 GBYes
RTX 4060Probably, at 4-bit
Mac with 32 GBYes
Mac with 64 GBYes
Mac with 128 GBYes

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Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.