Can I run Sharp-Spark-X2.5-4B-GGUF on a Mac with 64 GB?

Yes

Its Q6_K_XL file (3.61 GB) fits in the 48.0 GB a Mac with 64 GB can use, with room for ≈ 1M tokens of context.

ollama run hf.co/peculiar-ragdoll/Sharp-Spark-X2.5-4B-GGUF:Q6_K_XL

Files and context on Mac with 64 GB

Each file of Sharp-Spark-X2.5-4B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

Sharp-Spark-X2.5-4B-GGUF on other hardware

Popular models that run on Mac with 64 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.