Can I run Laguna-XS-2.1 on an RTX PRO 6000 Blackwell?

Yes

Its published weights (66.9 GB) fit in the 86.4 GB an RTX PRO 6000 Blackwell can use, with room for ≈ 256K tokens of context.

Full analysis of Laguna-XS-2.1 Everything that runs on RTX PRO 6000 Blackwell Get the weights on Hugging Face

hf download poolside/Laguna-XS-2.1

Files and context on RTX PRO 6000 Blackwell

Each file of Laguna-XS-2.1 (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On RTX PRO 6000 Blackwell	Context (16-bit)	Context (8-bit)
As published	66.9 GB	Fits	256K	256K
4-bit (estimate)	18.8 GB	Fits	256K	256K

Laguna-XS-2.1 on other hardware

NVIDIA H100Yes, just
RTX 5090Probably, at 4-bit
RTX 4090Probably, at 4-bit
RTX 3090Probably, at 4-bit
RTX 5060 Ti 16 GBNo
RTX 3060 12 GBNo
RTX 4060No
RTX PRO 6000 BlackwellYes
Mac with 32 GBProbably, at 4-bit
Mac with 64 GBProbably, at 4-bit
Mac with 128 GBYes

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Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.