Can I run Bonsai-27B-gguf on an RTX 5060?

Yes

Its Bonsai-27B-Q1_0 file (3.80 GB) fits in the 7.20 GB an RTX 5060 can use, with room for ≈ 4K tokens of context.

ollama run hf.co/prism-ml/Bonsai-27B-gguf

Files and context on RTX 5060

Each file of Bonsai-27B-gguf (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

Bonsai-27B-gguf on other hardware

Popular models that run on RTX 5060

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.