Can I run HunyuanOCR on a Mac with 256 GB?

Yes

Its published weights (2.24 GB) fit in the 192 GB a Mac with 256 GB can use, with room for ≈ 128K tokens of context.

hf download tencent/HunyuanOCR

Files and context on Mac with 256 GB

Each file of HunyuanOCR (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

HunyuanOCR on other hardware

Popular models that run on Mac with 256 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.