Can I run Youtu-Parsing-Omni on a Mac with 512 GB?

Yes

Its published weights (10.7 GB) fit in the 384 GB a Mac with 512 GB can use, with room for ≈ 1M tokens of context.

hf download tencent/Youtu-Parsing-Omni

Files and context on Mac with 512 GB

Each file of Youtu-Parsing-Omni (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

Youtu-Parsing-Omni on other hardware

Popular models that run on Mac with 512 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.