Can I run GLM-5.3-Flash-GGUF on an NVIDIA B200?

Yes

Its UD-IQ3_XXS file (120 GB) fits in the 162 GB an NVIDIA B200 can use, with room for an unknown amount of context.

llama-server -hf unsloth/GLM-5.3-Flash-GGUF:UD-IQ3_XXS

Files and context on NVIDIA B200

Each file of GLM-5.3-Flash-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

GLM-5.3-Flash-GGUF on other hardware

Popular models that run on NVIDIA B200

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.