Can I run GLM-5.3-Flash-GGUF on a Mac with 192 GB?

Yes

Its UD-Q2_K_XL file (109 GB) fits in the 144 GB a Mac with 192 GB can use, with room for an unknown amount of context. That file is under 3 bits per weight, so expect noticeably lower quality.

llama-server -hf unsloth/GLM-5.3-Flash-GGUF:UD-Q2_K_XL

Files and context on Mac with 192 GB

Each file of GLM-5.3-Flash-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

GLM-5.3-Flash-GGUF on other hardware

Popular models that run on Mac with 192 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.