Can I run LFM2.5-24B-A2B-GGUF on an RTX 5090?

Yes, just

Its Q8_0 file (25.5 GB) fits in the 28.8 GB an RTX 5090 can use, with room for ≈ 128K tokens of context.

ollama run hf.co/unsloth/LFM2.5-24B-A2B-GGUF:Q8_0

Files and context on RTX 5090

Each file of LFM2.5-24B-A2B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

LFM2.5-24B-A2B-GGUF on other hardware

Popular models that run on RTX 5090

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.