Can I run Muse-Spark-Open-816B-A42B-GGUF on an NVIDIA B300?

Yes, just

Its UD-IQ2_XXS file (226 GB) fits in the 259 GB an NVIDIA B300 can use, with room for ≈ 495K tokens of context. That file is under 3 bits per weight, so expect noticeably lower quality.

llama-server -hf unsloth/Muse-Spark-Open-816B-A42B-GGUF:UD-IQ2_XXS

Files and context on NVIDIA B300

Each file of Muse-Spark-Open-816B-A42B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

Muse-Spark-Open-816B-A42B-GGUF on other hardware

Popular models that run on NVIDIA B300

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.