Can I run Muse-Spark-Open-816B-A42B-GGUF on a Mac with 256 GB?

Yes, just

Its UD-IQ1_S file (176 GB) fits in the 192 GB a Mac with 256 GB can use, with room for ≈ 238K tokens of context. That file is under 3 bits per weight, so expect noticeably lower quality.

llama-server -hf unsloth/Muse-Spark-Open-816B-A42B-GGUF:UD-IQ1_S

Files and context on Mac with 256 GB

Each file of Muse-Spark-Open-816B-A42B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

Muse-Spark-Open-816B-A42B-GGUF on other hardware

Popular models that run on Mac with 256 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.