Can I run Qwen3.6-35B-A3B-MTP-GGUF on an RTX 5080?

Yes, just

Its UD-IQ3_XXS file (14.1 GB) fits in the 14.4 GB an RTX 5080 can use, with room for ≈ 13K tokens of context.

ollama run hf.co/unsloth/Qwen3.6-35B-A3B-MTP-GGUF:UD-IQ3_XXS

Files and context on RTX 5080

Each file of Qwen3.6-35B-A3B-MTP-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

Qwen3.6-35B-A3B-MTP-GGUF on other hardware

Popular models that run on RTX 5080

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.