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Can I run moondream2 on a Mac with 128 GB?

Yes

Its published weights (3.85 GB) fit in the 96.0 GB a Mac with 128 GB can use, with room for an unknown amount of context.

Full analysis of moondream2 Everything that runs on Mac with 128 GB Get the weights on Hugging Face
hf download vikhyatk/moondream2

Files and context on Mac with 128 GB

Each file of moondream2 (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 128 GB Context (16-bit)Context (8-bit)
As published3.85 GBFitsnot knownnot known
4-bit (estimate)1.08 GBFitsnot knownnot known

moondream2 on other hardware

Popular models that run on Mac with 128 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.