Can I run TwIL-LM3-Pro on an RTX 5060 Ti 16 GB?

Yes

Its published weights (7.32 GB) fit in the 14.4 GB an RTX 5060 Ti 16 GB can use, with room for ≈ 84K tokens of context.

Full analysis of TwIL-LM3-Pro Everything that runs on RTX 5060 Ti 16 GB Get the weights on Hugging Face

hf download webAI-Official/TwIL-LM3-Pro

Files and context on RTX 5060 Ti 16 GB

Each file of TwIL-LM3-Pro (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On RTX 5060 Ti 16 GB	Context (16-bit)	Context (8-bit)
As published	7.32 GB	Fits	84K	128K
4-bit (estimate)	2.06 GB	Fits	128K	128K

TwIL-LM3-Pro on other hardware

NVIDIA H100Yes
RTX 5090Yes
RTX 4090Yes
RTX 3090Yes
RTX 5060 Ti 16 GBYes
RTX 3060 12 GBYes
RTX 4060Probably, at 4-bit
Mac with 32 GBYes
Mac with 64 GBYes
Mac with 128 GBYes

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Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.