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Can I run GLM-4.5-Air on a Mac with 512 GB?

Yes

Its published weights (221 GB) fit in the 384 GB a Mac with 512 GB can use, with room for ≈ 128K tokens of context.

Full analysis of GLM-4.5-Air Everything that runs on Mac with 512 GB Get the weights on Hugging Face
hf download zai-org/GLM-4.5-Air

Files and context on Mac with 512 GB

Each file of GLM-4.5-Air (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 512 GB Context (16-bit)Context (8-bit)
As published221 GBFits128K128K
4-bit (estimate)62.1 GBFits128K128K

GLM-4.5-Air on other hardware

Popular models that run on Mac with 512 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.