Can I run GLM-5.3-Flash on an RTX 3090?

No

Even its smallest file (4-bit (estimate), 181 GB) is more than an RTX 3090 can hold (21.6 GB usable): it needs more than 8 of them.

Files and context on RTX 3090

Each file of GLM-5.3-Flash (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

GLM-5.3-Flash on other hardware

Popular models that run on RTX 3090

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.