Can I run gpt-neox-20b on an RTX 5090?

Probably, at 4-bit

The published weights are too big, but a 4-bit version (about 11.7 GB) would fit, with room for ≈ 2K tokens of context. The site hasn't analyzed a GGUF of gpt-neox-20b yet.

Files and context on RTX 5090

Each file of gpt-neox-20b (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

gpt-neox-20b on other hardware

Popular models that run on RTX 5090

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.