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Can I run Qwen3-235B-A22B-GGUF on a Mac with 64 GB?

No

Even its smallest file (Q4_K_M, 142 GB) is more than a Mac with 64 GB can hold (48.0 GB usable): it needs a Mac with 192 GB.

Full analysis of Qwen3-235B-A22B-GGUF Everything that runs on Mac with 64 GB

Files and context on Mac with 64 GB

Each file of Qwen3-235B-A22B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 64 GB Context (16-bit)Context (8-bit)
Q8_0250 GBDoesn't fit——
Q6_K193 GBDoesn't fit——
Q5_K_M167 GBDoesn't fit——
Q5_0162 GBDoesn't fit——
Q4_K_M142 GBDoesn't fit——

Qwen3-235B-A22B-GGUF on other hardware

Popular models that run on Mac with 64 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.