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Can I run Qwen3-235B-A22B-GGUF on an RTX 3090?

No

Even its smallest file (Q4_K_M, 142 GB) is more than an RTX 3090 can hold (21.6 GB usable): it needs 7 of them.

Full analysis of Qwen3-235B-A22B-GGUF Everything that runs on RTX 3090

Files and context on RTX 3090

Each file of Qwen3-235B-A22B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn RTX 3090 Context (16-bit)Context (8-bit)
Q8_0250 GBDoesn't fit——
Q6_K193 GBDoesn't fit——
Q5_K_M167 GBDoesn't fit——
Q5_0162 GBDoesn't fit——
Q4_K_M142 GBDoesn't fit——

Qwen3-235B-A22B-GGUF on other hardware

Popular models that run on RTX 3090

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.