Can I run Qwen3-Next-80B-A3B-Thinking-GGUF on a Mac with 512 GB?

Yes

Its Qwen3-Next-80B-A3B-Thinking file (159 GB) fits in the 384 GB a Mac with 512 GB can use, with room for ≈ 256K tokens of context.

Full analysis of Qwen3-Next-80B-A3B-Thinking-GGUF Everything that runs on Mac with 512 GB Get the Qwen3-Next-80B-A3B-Thinking file on Hugging Face

llama-server -hf Qwen/Qwen3-Next-80B-A3B-Thinking-GGUF

Files and context on Mac with 512 GB

Each file of Qwen3-Next-80B-A3B-Thinking-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On Mac with 512 GB	Context (16-bit)	Context (8-bit)
Qwen3-Next-80B-A3B-Thinking	159 GB	Fits	256K	256K
Q8_0	84.8 GB	Fits	256K	256K
Q6_K	65.5 GB	Fits	256K	256K
Q5_K_M	56.7 GB	Fits	256K	256K
Q5_0	55.0 GB	Fits	256K	256K
Q4_K_M	48.4 GB	Fits	256K	256K

Qwen3-Next-80B-A3B-Thinking-GGUF on other hardware

Popular models that run on Mac with 512 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.