Can I run blip2-opt-2.7b on a Radeon RX 7900 XTX?

Yes

Its published weights (15.0 GB) fit in the 21.6 GB a Radeon RX 7900 XTX can use, with room for ≈ 20K tokens of context.

Full analysis of blip2-opt-2.7b Everything that runs on Radeon RX 7900 XTX Get the weights on Hugging Face

hf download Salesforce/blip2-opt-2.7b

Files and context on Radeon RX 7900 XTX

Each file of blip2-opt-2.7b (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On Radeon RX 7900 XTX	Context (16-bit)	Context (8-bit)
As published	15.0 GB	Fits	20K	39K
4-bit (estimate)	2.11 GB	Fits	58K	116K

blip2-opt-2.7b on other hardware

NVIDIA H100Yes
RTX 5090Yes
RTX 4090Yes
RTX 3090Yes
RTX 5060 Ti 16 GBProbably, at 4-bit
RTX 3060 12 GBProbably, at 4-bit
RTX 4060Probably, at 4-bit
Radeon RX 7900 XTXYes
Mac with 32 GBYes
Mac with 64 GBYes
Mac with 128 GBYes

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Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.