Can I run NeoHorse-1-4B on a Mac with 16 GB?

Yes

Its published weights (8.41 GB) fit in the 10.7 GB a Mac with 16 GB can use, with room for ≈ 66K tokens of context.

Full analysis of NeoHorse-1-4B Everything that runs on Mac with 16 GB Get the weights on Hugging Face

hf download TokenRhythm/NeoHorse-1-4B

Files and context on Mac with 16 GB

Each file of NeoHorse-1-4B (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On Mac with 16 GB	Context (16-bit)	Context (8-bit)
As published	8.41 GB	Fits	66K	131K
BF16TokenRhythm/NeoHorse-1-4B-GGUF	8.42 GB	Fits	65K	131K
F16TokenRhythm/NeoHorse-1-4B-GGUF	8.42 GB	Fits	65K	131K
Q8_0TokenRhythm/NeoHorse-1-4B-GGUF	4.48 GB	Fits	183K	256K
Q5_K_MTokenRhythm/NeoHorse-1-4B-GGUF	3.07 GB	Fits	225K	256K
Q4_K_MTokenRhythm/NeoHorse-1-4B-GGUF	2.71 GB	Fits	236K	256K

NeoHorse-1-4B on other hardware

Popular models that run on Mac with 16 GB

Assumes 67% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.