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Can I run Tess-4.5-27B-GGUF on an NVIDIA B300?

Yes

Its Q8_0 file (28.6 GB) fits in the 259 GB an NVIDIA B300 can use, with room for ≈ 256K tokens of context.

Full analysis of Tess-4.5-27B-GGUF Everything that runs on NVIDIA B300 Get the Q8_0 file on Hugging Face
ollama run hf.co/migtissera/Tess-4.5-27B-GGUF:Q8_0

Files and context on NVIDIA B300

Each file of Tess-4.5-27B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn NVIDIA B300 Context (16-bit)Context (8-bit)
Q8_028.6 GBFits256K256K
Q6_K22.1 GBFits256K256K
Q4_K_M16.5 GBFits256K256K

Tess-4.5-27B-GGUF on other hardware

Popular models that run on NVIDIA B300

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.