Can I run gpt-oss-120b on an NVIDIA H100?

Yes, just

Its published weights (65.2 GB) fit in the 72.0 GB an NVIDIA H100 can use, with room for ≈ 128K tokens of context.

Full analysis of gpt-oss-120b Everything that runs on NVIDIA H100 Get the weights on Hugging Face

hf download openai/gpt-oss-120b

Files and context on NVIDIA H100

Each file of gpt-oss-120b (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On NVIDIA H100	Context (16-bit)	Context (8-bit)
As published	65.2 GB	Tight	128K	128K

gpt-oss-120b on other hardware

NVIDIA H100Yes, just
RTX 5090No
RTX 4090No
RTX 3090No
RTX 5060 Ti 16 GBNo
RTX 3060 12 GBNo
RTX 4060No
Mac with 32 GBNo
Mac with 64 GBNo
Mac with 128 GBYes

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Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.