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Can I run gpt-oss-120b on a Mac with 32 GB?

No

Even its smallest file (As published, 65.2 GB) is more than a Mac with 32 GB can hold (21.3 GB usable): it needs a Mac with 96 GB.

Full analysis of gpt-oss-120b Everything that runs on Mac with 32 GB

Files and context on Mac with 32 GB

Each file of gpt-oss-120b (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 32 GB Context (16-bit)Context (8-bit)
As published65.2 GBDoesn't fit——

gpt-oss-120b on other hardware

Popular models that run on Mac with 32 GB

Assumes 67% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.