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Can I run Ornith-1.5-397B-GGUF on a Mac with 512 GB?

Yes, just

Its Q6_K file (331 GB) fits in the 384 GB a Mac with 512 GB can use, with room for ≈ 256K tokens of context.

Full analysis of Ornith-1.5-397B-GGUF Everything that runs on Mac with 512 GB Get the Q6_K file on Hugging Face
ollama run hf.co/ornith-ai/Ornith-1.5-397B-GGUF:Q6_K

Files and context on Mac with 512 GB

Each file of Ornith-1.5-397B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 512 GB Context (16-bit)Context (8-bit)
Q8_0429 GBDoesn't fit——
Q6_K331 GBTight256K256K
Q5_K_M286 GBFits256K256K
Q4_K_M244 GBFits256K256K

Ornith-1.5-397B-GGUF on other hardware

Popular models that run on Mac with 512 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.