Can I run Qwen3.8-27B-DSpine-b16 on an RTX PRO 6000 Blackwell?

Yes

Its published weights (4.05 GB) fit in the 86.4 GB an RTX PRO 6000 Blackwell can use, with room for ≈ 256K tokens of context.

Full analysis of Qwen3.8-27B-DSpine-b16 Everything that runs on RTX PRO 6000 Blackwell Get the weights on Hugging Face

hf download tencent/Qwen3.8-27B-DSpine-b16

Files and context on RTX PRO 6000 Blackwell

Each file of Qwen3.8-27B-DSpine-b16 (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On RTX PRO 6000 Blackwell	Context (16-bit)	Context (8-bit)
As published	4.05 GB	Fits	256K	256K
BF16aj9o9/Qwen3.8-27B-DSpine-b16-GGUF	4.06 GB	Fits	256K	256K
Q8_0aj9o9/Qwen3.8-27B-DSpine-b16-GGUF	2.20 GB	Fits	256K	256K
Q4_K_Maj9o9/Qwen3.8-27B-DSpine-b16-GGUF	1.26 GB	Fits	256K	256K

Qwen3.8-27B-DSpine-b16 on other hardware

Popular models that run on RTX PRO 6000 Blackwell

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.