Can I run gpt-oss-120b on an RTX PRO 6000 Blackwell?

Yes

Its published weights (65.2 GB) fit in the 86.4 GB an RTX PRO 6000 Blackwell can use, with room for ≈ 128K tokens of context.

Full analysis of gpt-oss-120b Everything that runs on RTX PRO 6000 Blackwell Get the weights on Hugging Face

hf download openai/gpt-oss-120b

Files and context on RTX PRO 6000 Blackwell

Each file of gpt-oss-120b (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On RTX PRO 6000 Blackwell	Context (16-bit)	Context (8-bit)
As published	65.2 GB	Fits	128K	128K

gpt-oss-120b on other hardware

NVIDIA H100Yes, just
RTX 5090No
RTX 4090No
RTX 3090No
RTX 5060 Ti 16 GBNo
RTX 3060 12 GBNo
RTX 4060No
RTX PRO 6000 BlackwellYes
Mac with 32 GBNo
Mac with 64 GBNo
Mac with 128 GBYes

Popular models that run on RTX PRO 6000 Blackwell

Qwen3-0.6BQwen · 752M
Qwen3-VL-8B-InstructQwen · 8.77B
gpt2openai-community · 137M
Qwen3-8BQwen · 8.19B
Qwen3-Coder-30B-A3B-Instruct-GGUFunsloth · 30.5B
gemma-4-26B-A4B-itgoogle · 25.8B
Qwen2.5-7B-InstructQwen · 7.62B
Qwen3.5-9BQwen · 9.65B

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.