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Can I run Signal-3.8-27B-GGUF on an RTX 3090?

Yes, just

Its Q5_K_M file (19.5 GB) fits in the 21.6 GB an RTX 3090 can use, with room for ≈ 28K tokens of context.

Full analysis of Signal-3.8-27B-GGUF Everything that runs on RTX 3090 Get the Q5_K_M file on Hugging Face
ollama run hf.co/agentionai/Signal-3.8-27B-GGUF:Q5_K_M

Files and context on RTX 3090

Each file of Signal-3.8-27B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn RTX 3090 Context (16-bit)Context (8-bit)
Q8_029.0 GBDoesn't fit——
Q6_K22.4 GBDoesn't fit——
Q5_K_M19.5 GBTight28K57K
Q4_K_XL17.6 GBTight58K116K
Q4_K_M17.0 GBFits66K133K
Q3_K_XL15.1 GBFits95K189K
IQ4_XS14.3 GBFits107K214K
IQ3_S13.3 GBFits122K243K
IQ3_XXS12.2 GBFits137K256K

Signal-3.8-27B-GGUF on other hardware

Popular models that run on RTX 3090

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.