Can I run Signal-3.8-27B-GGUF on an RTX 4060?
No
Even its smallest file (IQ3_XXS, 12.2 GB) is more than an RTX 4060 can hold (7.20 GB usable): it needs 2 of them.
Files and context on RTX 4060
Each file of Signal-3.8-27B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.