Can I run Signal-3.8-27B-GGUF on an RTX 5060 Ti 16 GB?

Yes, just

Its IQ3_S file (13.3 GB) fits in the 14.4 GB an RTX 5060 Ti 16 GB can use, with room for ≈ 14K tokens of context.

ollama run hf.co/agentionai/Signal-3.8-27B-GGUF:IQ3_S

Files and context on RTX 5060 Ti 16 GB

Each file of Signal-3.8-27B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

Signal-3.8-27B-GGUF on other hardware

Popular models that run on RTX 5060 Ti 16 GB

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.